Danny (Chris Pine) is an intelligent and handsome young man who also happens to be blind, but he refuses to let that get in the way of anything. He's one of the most popular guys in town, which is why his brother Larry (Eddie Kaye Thomas) is shocked to find out that he shy and nervous around women and also a virgin. Larry decides to set Danny on a series of blind dates with shallow girls, which all turn out badly, and just when Danny is ready to give up on love, he meets a young Indian nurse named Leeza (Anjali Jay).