In this remake of a 1976 film of the same title, Henry Griffin (Dermot Mulroney) is divorced and doctors have confirmed that he has inoperable cancer. In order to live the rest of his remaining life to the fullest, he quits his job and moves to Greenwich Village. There he meets and falls in love with academic advisor Sarah Phoenix (Amanda Peet) and the pair decide to fulfill all of Henry's childhood fantasies, but it turns out that Sarah also has a secret, she is also ill.